PHARMACUETICAL COMPANIES

At PRADO, we understand how important on-time delivery is for meeting your goals for IND, NDA, and other regulatory submissions. As your development partner, we will work side-by-side with you to learn the particulars of your application, and deliver timely reports with results you can use and depend on.

PRADO's Pharma Product Development Services includes:

Toxicity Studies

  • Acute toxicity studies.
  • Guinea Pig Maximization Test (GPMT) / Buhler SensitizationTest.
  • Sub-acute toxicity studies.
  • Sub-chronic toxicity studies.
  • Chronic Toxicity Studies.
  • Genetic toxicity studies.
  • Reproductive toxicity studies.

DMPK and ADME studies including

  • Single, multiple and cassette dosing; Dose escalation study;Determination of fundamental PK parameters.
  • Tissue distribution study; Blood brain barrier.
  • Rank-ordering compounds/formulations.
  • PK-PD Evaluation.
  • Species Used includes
  • Rat, Mice, Rabbit, Guinea Pig.
  • Pig, Dog (3rd Party Collaboration).
  • Routes of administration includes
  • Oral, intravenous (bolus and infusion), intra-peritoneal, subcutaneous, intranasal, intramuscular, intra-rectal or intra-ocular.
  • Biological Matrices includes
  • Blood/plasma/urine/feces.
  • Bile, Cerebrospinal fluid.
  • Various tissues such as brain, lung, heart, liver, kidney, spleen, skeletal muscle.
  • Ocular tissues like aqueous humor, vitreous humor, lens, cornea, optic nerve.

Biology

  • Inflammation and Pain Models.
  • Metabolic Disorders Models.
  • Antipsychotic Activity Models.
  • Osteoporosis Models.
  • Safety Pharmacology Models.

Pathology Evaluation Services:

We understand that it requires large amounts of pathology data to be collected, prepared, evaluated and interpreted in a timely manner in order to meet your development goal. We offer independent pathology laboratory services which includes;

  • Necropsy.
  • Histopathology slide preparation.
  • H & E staining.
  • Special staining.
  • Hematology.
  • Clinical chemistry.
  • Urinalysis.
  • Coagulation

PDE calculations

  • Determination ofthe Permitted Daily Exposure (PDE) of chemicals. The PDE represents a substance-specific dose that is unlikely to cause an adverse effect if an individual is exposed at or below this dose every day for a lifetime.

Copyright © Prado Pvt. Ltd. All rights reserved.