{"id":367,"date":"2025-08-12T16:50:58","date_gmt":"2025-08-12T16:50:58","guid":{"rendered":"https:\/\/prado.mindconic.com\/?page_id=367"},"modified":"2025-08-21T13:42:09","modified_gmt":"2025-08-21T13:42:09","slug":"pharmacokinetic","status":"publish","type":"page","link":"https:\/\/pradopreclinical.com\/?page_id=367","title":{"rendered":"Pharmacokinetic"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"367\" class=\"elementor elementor-367\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-668847b e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"668847b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5d6636f e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"5d6636f\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bf5fed0 elementor-widget__width-initial elementor-widget elementor-widget-elementskit-heading\" data-id=\"bf5fed0\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_center   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Pharmacokinetics (PK)and <br>Toxicokinetics (TK) Services<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-355cdbe e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"355cdbe\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-adc7cfd e-n-tabs-mobile elementor-widget elementor-widget-n-tabs\" data-id=\"adc7cfd\" data-element_type=\"widget\" data-widget_type=\"nested-tabs.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-tabs\" data-widget-number=\"182222077\" aria-label=\"Tabs. Open items with Enter or Space, close with Escape and navigate using the Arrow keys.\">\n\t\t\t<div class=\"e-n-tabs-heading\" role=\"tablist\">\n\t\t\t\t\t<button id=\"e-n-tab-title-1822220771\" class=\"e-n-tab-title\" aria-selected=\"true\" data-tab-index=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"e-n-tab-content-1822220771\" style=\"--n-tabs-title-order: 1;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tDrug Absorption, Distribution, Metabolism, Excretion (ADME) and Kinetics\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1822220772\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1822220772\" style=\"--n-tabs-title-order: 2;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tDose Response and Linearity\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1822220773\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1822220773\" style=\"--n-tabs-title-order: 3;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tTissue Distribution\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1822220774\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1822220774\" style=\"--n-tabs-title-order: 4;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tPK Parameter Determination\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1822220775\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1822220775\" style=\"--n-tabs-title-order: 5;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tBlood-Brain Barrier Studies:\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1822220776\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"6\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1822220776\" style=\"--n-tabs-title-order: 6;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tContinuous Infusion PK\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-1822220771\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1822220771\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-51a03b6 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"51a03b6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b2eab0 elementor-widget elementor-widget-heading\" data-id=\"7b2eab0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Drug Absorption, Distribution, Metabolism, Excretion (ADME) and Kinetics<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c1e1cc elementor-widget elementor-widget-text-editor\" data-id=\"4c1e1cc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0Comprehensive analysis of how a drug moves through the body, including studies for single, multiple, and cassette dosing.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da6f446 elementor-widget elementor-widget-image\" data-id=\"da6f446\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg\" class=\"attachment-large size-large wp-image-483\" alt=\"\" srcset=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg 600w, https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1822220772\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1822220772\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\" elementor-element elementor-element-f63d058 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"f63d058\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aa8d4c2 elementor-widget elementor-widget-heading\" data-id=\"aa8d4c2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Dose Response and Linearity:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88e81ba elementor-widget elementor-widget-text-editor\" data-id=\"88e81ba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0Determining dose escalation and range-finding studies to understand the relationship between dose and effect.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b6167e3 elementor-widget elementor-widget-image\" data-id=\"b6167e3\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg\" class=\"attachment-large size-large wp-image-483\" alt=\"\" srcset=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg 600w, https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1822220773\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1822220773\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\" elementor-element elementor-element-e776d78 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"e776d78\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cecd394 elementor-widget elementor-widget-heading\" data-id=\"cecd394\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Tissue Distribution<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b5c8c73 elementor-widget elementor-widget-text-editor\" data-id=\"b5c8c73\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Investigating where a substance goes in the body, including distribution in organs like the brain, heart, liver, lung, kidney, and ocular tissues (aqueous humor, vitreous humor, lens, cornea, optic nerve).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-92fa150 elementor-widget elementor-widget-image\" data-id=\"92fa150\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg\" class=\"attachment-large size-large wp-image-483\" alt=\"\" srcset=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg 600w, https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1822220774\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1822220774\" data-tab-index=\"4\" style=\"--n-tabs-title-order: 4;\" class=\" elementor-element elementor-element-9c7a51c e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"9c7a51c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bb25252 elementor-widget elementor-widget-heading\" data-id=\"bb25252\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PK Parameter Determination<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0e286c5 elementor-widget elementor-widget-text-editor\" data-id=\"0e286c5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0Calculating key pharmacokinetic parameters such as maximum plasma concentration (Cmax), time to reach Cmax (Tmax), area under the curve (AUC), clearance rates, oral bioavailability, and volume of distribution.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10a1cf8 elementor-widget elementor-widget-image\" data-id=\"10a1cf8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg\" class=\"attachment-large size-large wp-image-483\" alt=\"\" srcset=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg 600w, https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1822220775\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1822220775\" data-tab-index=\"5\" style=\"--n-tabs-title-order: 5;\" class=\" elementor-element elementor-element-db834ed e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"db834ed\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9325ec8 elementor-widget elementor-widget-heading\" data-id=\"9325ec8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Blood-Brain Barrier Studies<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-85fb4b9 elementor-widget elementor-widget-text-editor\" data-id=\"85fb4b9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0Assessing a substance&#8217;s ability to cross the blood-brain barrier.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c9a278 elementor-widget elementor-widget-image\" data-id=\"2c9a278\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg\" class=\"attachment-large size-large wp-image-483\" alt=\"\" srcset=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg 600w, https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1822220776\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1822220776\" data-tab-index=\"6\" style=\"--n-tabs-title-order: 6;\" class=\" elementor-element elementor-element-a3a4768 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"a3a4768\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7fcae50 elementor-widget elementor-widget-heading\" data-id=\"7fcae50\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Continuous Infusion PK<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bd98a2c elementor-widget elementor-widget-text-editor\" data-id=\"bd98a2c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0Evaluating the pharmacokinetics of continuously infused compounds.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0e2acdb elementor-widget elementor-widget-image\" data-id=\"0e2acdb\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg\" class=\"attachment-large size-large wp-image-483\" alt=\"\" srcset=\"https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok.jpg 600w, https:\/\/pradopreclinical.com\/wp-content\/uploads\/2025\/08\/pharmok-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Pharmacokinetics (PK)and Toxicokinetics (TK) Services Drug Absorption, Distribution, Metabolism, Excretion (ADME) and Kinetics Dose Response and Linearity Tissue Distribution PK Parameter Determination Blood-Brain Barrier Studies: Continuous Infusion PK Drug Absorption, Distribution, Metabolism, Excretion (ADME) and Kinetics \u00a0Comprehensive analysis of how a drug moves through the body, including studies for single, multiple, and cassette dosing. Dose Response and Linearity: \u00a0Determining dose escalation and range-finding studies to understand the relationship between dose and effect. Tissue Distribution Investigating where a substance goes in the body, including distribution in organs like the brain, heart, liver, lung, kidney, and ocular tissues (aqueous humor, vitreous humor, lens, cornea, optic nerve). PK Parameter Determination \u00a0Calculating key pharmacokinetic parameters such as maximum plasma concentration (Cmax), time to reach Cmax (Tmax), area under the curve (AUC), clearance rates, oral bioavailability, and volume of distribution. Blood-Brain Barrier Studies \u00a0Assessing a substance&#8217;s ability to cross the blood-brain barrier. Continuous Infusion PK \u00a0Evaluating the pharmacokinetics of continuously infused compounds. Drug Absorption, Distribution, Metabolism, Excretion (ADME) and Kinetics \u00a0Comprehensive analysis of how a drug moves through the body, including studies for single, multiple, and cassette dosing. Dose Response and Linearity: \u00a0Determining dose escalation and range-finding studies to understand the relationship between dose and effect. Tissue Distribution Investigating where a substance goes in the body, including distribution in organs like the brain, heart, liver, lung, kidney, and ocular tissues (aqueous humor, vitreous humor, lens, cornea, optic nerve). PK Parameter Determination \u00a0Calculating key pharmacokinetic parameters such as maximum plasma concentration (Cmax), time to reach Cmax (Tmax), area under the curve (AUC), clearance rates, oral bioavailability, and volume of distribution. Blood-Brain Barrier Studies \u00a0Assessing a substance&#8217;s ability to cross the blood-brain barrier. Continuous Infusion PK \u00a0Evaluating the pharmacokinetics of continuously infused compounds.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-367","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/pages\/367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=367"}],"version-history":[{"count":13,"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/pages\/367\/revisions"}],"predecessor-version":[{"id":618,"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/pages\/367\/revisions\/618"}],"wp:attachment":[{"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}