{"id":369,"date":"2025-08-12T16:51:19","date_gmt":"2025-08-12T16:51:19","guid":{"rendered":"https:\/\/prado.mindconic.com\/?page_id=369"},"modified":"2025-08-21T14:05:16","modified_gmt":"2025-08-21T14:05:16","slug":"biology","status":"publish","type":"page","link":"https:\/\/pradopreclinical.com\/?page_id=369","title":{"rendered":"Pharmacology &amp; Efficacy StudiesBiology"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"369\" class=\"elementor elementor-369\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8a6d12d e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"8a6d12d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-861f8f2 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"861f8f2\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4992528 elementor-widget__width-initial elementor-widget elementor-widget-elementskit-heading\" data-id=\"4992528\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_center   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Pharmacology &amp; Efficacy Studies<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-88bad6b e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"88bad6b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-637a09d e-n-tabs-mobile elementor-widget elementor-widget-n-tabs\" data-id=\"637a09d\" data-element_type=\"widget\" data-widget_type=\"nested-tabs.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-tabs\" data-widget-number=\"104308893\" aria-label=\"Tabs. Open items with Enter or Space, close with Escape and navigate using the Arrow keys.\">\n\t\t\t<div class=\"e-n-tabs-heading\" role=\"tablist\">\n\t\t\t\t\t<button id=\"e-n-tab-title-1043088931\" class=\"e-n-tab-title\" aria-selected=\"true\" data-tab-index=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"e-n-tab-content-1043088931\" style=\"--n-tabs-title-order: 1;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tGeneral Biology &amp; Efficacy Models:\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1043088932\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1043088932\" style=\"--n-tabs-title-order: 2;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tInflammation &amp; Pain Models\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1043088933\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1043088933\" style=\"--n-tabs-title-order: 3;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tAntipsychotic Activity Models\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1043088934\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1043088934\" style=\"--n-tabs-title-order: 4;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tMetabolic Disorders Models\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1043088935\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1043088935\" style=\"--n-tabs-title-order: 5;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tSafety Pharmacology Models\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1043088936\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"6\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1043088936\" style=\"--n-tabs-title-order: 6;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tOsteoporosis Models\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-1043088931\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1043088931\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-8474c4d e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"8474c4d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-839406c elementor-widget elementor-widget-heading\" data-id=\"839406c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">General Biology &amp; Efficacy Models<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4366e68 elementor-widget elementor-widget-text-editor\" data-id=\"4366e68\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Conducting studies to determine how well a substance works. This includes a variety of in vitro and in vivo (animal) models across different therapeutic areas.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1043088932\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1043088932\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\" elementor-element elementor-element-4d42962 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"4d42962\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f44ed14 elementor-widget elementor-widget-heading\" data-id=\"f44ed14\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Inflammation &amp; Pain Models<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8d71446 elementor-widget elementor-widget-text-editor\" data-id=\"8d71446\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0Investigating the effectiveness of compounds against inflammatory and pain conditions using models such as collagen-induced arthritis, DSS or acetic acid-induced colitis, psoriasis-like skin disease, excision wound healing, osteoarthritis, carrageenan-induced paw edema, and models for mechanical, thermal, cold hyperalgesia, and neuropathic pain (e.g., spinal nerve ligation, partial sciatic nerve ligation, etc).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1043088933\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1043088933\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\" elementor-element elementor-element-da44f90 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"da44f90\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c3682f9 elementor-widget elementor-widget-heading\" data-id=\"c3682f9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Antipsychotic Activity Models<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d58510 elementor-widget elementor-widget-text-editor\" data-id=\"9d58510\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0Assessing compounds for their potential to treat psychosis and related neurobehavioral disorders, using tests like the Novel Object Recognition Test, social interaction deficits, disruption of Conditioned Avoidance Response, restoration of pre-pulse inhibition (PPI), and various neurobehavioral assays.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1043088934\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1043088934\" data-tab-index=\"4\" style=\"--n-tabs-title-order: 4;\" class=\" elementor-element elementor-element-059bb69 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"059bb69\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6106616 elementor-widget elementor-widget-heading\" data-id=\"6106616\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Metabolic Disorders Models<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7fbffe3 elementor-widget elementor-widget-text-editor\" data-id=\"7fbffe3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0Studying interventions for conditions like STZ-induced diabetes, diabetic neuropathy, hypothyroidism, and acute or chronic kidney diseases in rodent models.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1043088935\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1043088935\" data-tab-index=\"5\" style=\"--n-tabs-title-order: 5;\" class=\" elementor-element elementor-element-8dd879b e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"8dd879b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-984b5bf elementor-widget elementor-widget-heading\" data-id=\"984b5bf\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Safety Pharmacology Models<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c756d7a elementor-widget elementor-widget-text-editor\" data-id=\"c756d7a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0Evaluating the potential adverse effects of substances on vital bodily functions (e.g., central nervous system, cardiovascular, respiratory) using tests like rota rod, grip strength, tail flick, hot plate, and non-invasive blood pressure recording.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1043088936\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1043088936\" data-tab-index=\"6\" style=\"--n-tabs-title-order: 6;\" class=\" elementor-element elementor-element-162f73c e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"162f73c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b4cf7ee elementor-widget elementor-widget-heading\" data-id=\"b4cf7ee\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Osteoporosis Models<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-18d7357 elementor-widget elementor-widget-text-editor\" data-id=\"18d7357\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Researching potential treatments for bone density loss using models such as ovariectomy-induced osteoporosis, thyroxine or ethanol-induced osteoporosis, and hypercalcemia induced by retinoic acid.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Pharmacology &amp; Efficacy Studies General Biology &amp; Efficacy Models: Inflammation &amp; Pain Models Antipsychotic Activity Models Metabolic Disorders Models Safety Pharmacology Models Osteoporosis Models General Biology &amp; Efficacy Models Conducting studies to determine how well a substance works. This includes a variety of in vitro and in vivo (animal) models across different therapeutic areas. Inflammation &amp; Pain Models \u00a0Investigating the effectiveness of compounds against inflammatory and pain conditions using models such as collagen-induced arthritis, DSS or acetic acid-induced colitis, psoriasis-like skin disease, excision wound healing, osteoarthritis, carrageenan-induced paw edema, and models for mechanical, thermal, cold hyperalgesia, and neuropathic pain (e.g., spinal nerve ligation, partial sciatic nerve ligation, etc). Antipsychotic Activity Models \u00a0Assessing compounds for their potential to treat psychosis and related neurobehavioral disorders, using tests like the Novel Object Recognition Test, social interaction deficits, disruption of Conditioned Avoidance Response, restoration of pre-pulse inhibition (PPI), and various neurobehavioral assays. \u00a0 Metabolic Disorders Models \u00a0Studying interventions for conditions like STZ-induced diabetes, diabetic neuropathy, hypothyroidism, and acute or chronic kidney diseases in rodent models. Safety Pharmacology Models \u00a0Evaluating the potential adverse effects of substances on vital bodily functions (e.g., central nervous system, cardiovascular, respiratory) using tests like rota rod, grip strength, tail flick, hot plate, and non-invasive blood pressure recording. Osteoporosis Models Researching potential treatments for bone density loss using models such as ovariectomy-induced osteoporosis, thyroxine or ethanol-induced osteoporosis, and hypercalcemia induced by retinoic acid. General Biology &amp; Efficacy Models Conducting studies to determine how well a substance works. This includes a variety of in vitro and in vivo (animal) models across different therapeutic areas. Inflammation &amp; Pain Models \u00a0Investigating the effectiveness of compounds against inflammatory and pain conditions using models such as collagen-induced arthritis, DSS or acetic acid-induced colitis, psoriasis-like skin disease, excision wound healing, osteoarthritis, carrageenan-induced paw edema, and models for mechanical, thermal, cold hyperalgesia, and neuropathic pain (e.g., spinal nerve ligation, partial sciatic nerve ligation, etc). Antipsychotic Activity Models \u00a0Assessing compounds for their potential to treat psychosis and related neurobehavioral disorders, using tests like the Novel Object Recognition Test, social interaction deficits, disruption of Conditioned Avoidance Response, restoration of pre-pulse inhibition (PPI), and various neurobehavioral assays. \u00a0 Metabolic Disorders Models \u00a0Studying interventions for conditions like STZ-induced diabetes, diabetic neuropathy, hypothyroidism, and acute or chronic kidney diseases in rodent models. Safety Pharmacology Models \u00a0Evaluating the potential adverse effects of substances on vital bodily functions (e.g., central nervous system, cardiovascular, respiratory) using tests like rota rod, grip strength, tail flick, hot plate, and non-invasive blood pressure recording. Osteoporosis Models Researching potential treatments for bone density loss using models such as ovariectomy-induced osteoporosis, thyroxine or ethanol-induced osteoporosis, and hypercalcemia induced by retinoic acid.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-369","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/pages\/369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=369"}],"version-history":[{"count":21,"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/pages\/369\/revisions"}],"predecessor-version":[{"id":634,"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=\/wp\/v2\/pages\/369\/revisions\/634"}],"wp:attachment":[{"href":"https:\/\/pradopreclinical.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}